The value of ultrasonography for the indication of fine‐needle aspiration in autonomous thyroid nodules
| Autor: | Theara de Castro Nicolau, Pedro Weslley Rosario |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Thyroid nodules medicine.medical_specialty Histology Cytodiagnosis Biopsy Fine-Needle 030209 endocrinology & metabolism Malignancy Pathology and Forensic Medicine Young Adult 03 medical and health sciences 0302 clinical medicine Cytology Adenocarcinoma Follicular medicine Humans Prospective Studies Thyroid Neoplasms Thyroid Nodule Prospective cohort study Aged Ultrasonography Aged 80 and over Suspicious for Malignancy medicine.diagnostic_test business.industry Calcinosis General Medicine Middle Aged medicine.disease Carcinoma Papillary Fine-needle aspiration 030220 oncology & carcinogenesis Female Radiology Microcalcification medicine.symptom business |
| Zdroj: | Diagnostic Cytopathology. 49:363-366 |
| ISSN: | 1097-0339 8755-1039 |
| DOI: | 10.1002/dc.24659 |
| Popis: | Background The risk of malignancy in autonomous thyroid nodules is considered to be very low in adults and fine-needle aspiration (FNA) is not recommended in these cases; however, some studies contest this. Just as ultrasonography (US) has been used to select nonautonomous nodules with initial benign cytology that deserve FNA repetition, this method may also be useful to select autonomous nodules that are candidates for FNA. Methods In this prospective study, FNA was obtained in 48 adults patients with autonomous solitary nodules >1 cm with suspicious US features (at least two of the following findings: hypoechogenicity, microcalcification, irregular margins, taller than wider shape, predominantly or exclusively central vascularization). Results Cytology was benign in 28 patients (58.3%). Six patients (12.5%) had nondiagnostic cytology and histology revealed benign nodules in these cases. Cytology was indeterminate in nine other patients (18.5%). Of these, seven were adenomas and two were follicular carcinomas on histology. Finally, cytology suspicious for malignancy or malignant cytology was detected in five patients (10.4%), all of them confirmed histologically to be papillary carcinomas (the follicular variant in three). Thus, the frequency of malignancy was 14.6% (two follicular carcinomas and five papillary carcinomas), 8.3% in nodules with two suspicious findings vs 33.3% in nodules with ≥3 suspicious findings (P = .055). Conclusion The results suggest that the presence of ultrasonographic findings suspicious for malignancy in autonomous thyroid nodules >1 cm is a criterion for the indication of FNA. |
| Databáze: | OpenAIRE |
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