Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism
| Autor: | J. E. Robinson, M. Heilig, C. J. Malanga, Eric W. Fish, Michael C. Krouse, Annika Thorsell |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Quinuclidines Narcotic Antagonists Substance P Pharmacology Article Naltrexone Mice chemistry.chemical_compound Neurokinin-1 Receptor Antagonists Piperidines Reward Dopamine Tachykinin receptor 1 medicine Animals Dose-Response Relationship Drug Morphine business.industry musculoskeletal neural and ocular physiology Brain Long-term potentiation respiratory system Electric Stimulation Analgesics Opioid Mice Inbred C57BL nervous system chemistry Opioid Brain stimulation reward business Reinforcement Psychology Neuroscience medicine.drug |
| Zdroj: | Psychopharmacology. 220:215-224 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | The abuse potential of opioids may be due to their reinforcing and rewarding effects, which may be attenuated by neurokinin-1 receptor (NK1R) antagonists.This study was conducted to measure the effects of opioid and NK1R blockade on the potentiation of brain stimulation reward (BSR) by morphine using the intracranial self-stimulation method.Adult male C57BL/6J mice (n = 15) were implanted with unipolar stimulating electrodes in the lateral hypothalamus and trained to respond for varying frequencies of rewarding electrical stimulation. The BSR threshold (θ(0)) and maximum response rate (MAX) were determined before and after intraperitoneal administration of saline, morphine (1.0-17.0 mg/kg), or the NK1R antagonists L-733,060 (1.0-17.0 mg/kg) and L-703,606 (1.0-17.0 mg/kg). In morphine antagonism experiments, naltrexone (0.1-1.0 mg/kg) or 10.0 mg/kg L-733,060 or L-703,606 was administered 15 min before morphine (1.0-10.0 mg/kg) or saline.Morphine dose-dependently decreased θ(0) (maximum effect = 62% of baseline) and altered MAX when compared to saline. L-703,606 and L-733,060 altered θ(0); 10.0 mg/kg L-733,060 and L-703,606, which did not affect θ(0) or MAX, attenuated the effects of 3.0 and 10.0 mg/kg morphine, and 1.0 and 0.3 mg/kg naltrexone blocked the effects of 10.0 mg/kg morphine. Naltrexone given before saline did not affect θ(0) or MAX.The decrease in θ(0) by morphine reflects its rewarding effects, which were attenuated by NK1R and opioid receptor blockade. These results demonstrate the importance of substance P signaling during limbic reward system activation by opioids. |
| Databáze: | OpenAIRE |
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