Carpipramine metabolism in the rat, rabbit and dog and in man after oral administration
| Autor: | Bieder A, C. Gaillard, J. Gaillot, H. Depaire, L. Raynaud, C. Snozzi, Decouvelaere B |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Carpipramine medicine.medical_specialty Magnetic Resonance Spectroscopy Spectrophotometry Infrared Health Toxicology and Mutagenesis Molecular Conformation Urine Biology Hydroxylation Toxicology Biochemistry Mass Spectrometry Benzodiazepines Feces chemistry.chemical_compound Dogs Species Specificity Dibenzazepines Oral administration Internal medicine medicine Animals Humans Biotransformation Chromatography High Pressure Liquid Pharmacology Lagomorpha Rats Inbred Strains General Medicine Metabolism biology.organism_classification Rats Metabolic pathway Endocrinology Anti-Anxiety Agents chemistry Female Rabbits Piperidine |
| Zdroj: | Xenobiotica. 15:421-435 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.3109/00498258509045013 |
| Popis: | 1. Carpipramine administered orally is excreted via the urine and faeces in rat, rabbit, dog and man. Many metabolites are formed, including several conjugates in the urine.2. A total of 20–25 metabolites was detected by t.l.c. and h.p.l.c., 16 of which were isolated and identified.3. Three metabolic pathways were observed: (i) hydroxylation of the iminodibenzyl ring to a phenol or alcohol without modification of the side-chain, (ii) hydroxylation of the terminal piperidine of the 2-piperidinol side-chain, and (iii) cyclization and dehydrogenation of the same 2-piperidinol group. |
| Databáze: | OpenAIRE |
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