Inhibitors of hepatitis C virus NS3·4A protease 1. Non-Charged tetrapeptide variants

Autor:	Rhonda B. Levin, Luc J. Farmer, Robert B. Perni, Joseph L. Kim, Janos Pitlik, B. Govinda Rao, J. A. Landro, Wayne C. Schairer, Roger D. Tung, Shawn D. Britt, Cynthia A. Gates, David D. Deininger, John A. Thomson, John H. Van Drie, Lawrence F. Courtney, John Court, Ethan O'malley, Scott L. Harbeson, Yu-Ping Luong, Yunyi Wei
Rok vydání:	2003
Předmět:	Models Molecular Protein Conformation Peptidomimetic Stereochemistry viruses medicine.medical_treatment Hepacivirus Hepatitis C virus Clinical Biochemistry Pharmaceutical Science medicine.disease_cause Biochemistry Virus Structure-Activity Relationship X-Ray Diffraction Drug Discovery medicine Protease Inhibitors Protease inhibitor (pharmacology) Molecular Biology Protease biology Tetrapeptide Chemistry Organic Chemistry biology.organism_classification Kinetics Enzyme inhibitor biology.protein Molecular Medicine Oligopeptides
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:4059-4063
ISSN:	0960-894X
Popis:	Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the P1 and P2 inhibitor positions is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91046b82077f4245c43e468a535b331b https://doi.org/10.1016/j.bmcl.2003.08.050 Zobrazit plný text záznamu Full Text from ScienceDirect