Nuclear Ptdlns(3,4,5)P3 signaling: an ongoing story
| Autor: | Stéphanie Gayral, Monique Breton-Douillon, Paul Déléris |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cell Nucleus
Phosphoinositide 3-kinase biology Active Transport Cell Nucleus PTEN Phosphohydrolase Cell Biology Phosphatidylinositol 3-Kinases Biochemistry Cell biology Cell nucleus chemistry.chemical_compound medicine.anatomical_structure chemistry Phosphatidylinositol Phosphates Cell surface receptor Second messenger system biology.protein medicine PTEN Humans Phosphatidylinositol Signal transduction Molecular Biology Signal Transduction |
| Zdroj: | Journal of cellular biochemistry. 98(3) |
| ISSN: | 0730-2312 |
| Popis: | Phosphatidylinositol 3,4,5-trisphosphate (Ptdlns(3,4,5)P(3)) is linked to a variety of cellular functions, such as growth, cell survival, and differentiation. Ptdlns(3,4,5)P(3) is primarily synthesized by class I phosphoinositide 3-kinases and its hydrolysis by two 3-phosphoinositide 3-phosphatases, PTEN and SHIP proteins, leads to the production of two other second messengers, Ptdlns(4,5)P(2) and Ptdlns(3,4)P(2), respectively. Evidence accumulated over the last years strongly suggest that Ptdlns(3,4,5)P(3) is an important component of signaling pathway operating within the nucleus. Moreover, recent advances indicated that nuclear translocation of cell surface receptors could activate nuclear phosphoinositide 3-kinase suggesting a new mode of signal transduction. The aim of this review is intended to summarize the state of our knowledge on nuclear Ptdlns(3,4,5)P(3) and its metabolizing enzymes, and to highlight the emerging roles for intranuclear Ptdlns(3,4,5)P(3). |
| Databáze: | OpenAIRE |
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