Comparative cytotoxicities of selected minor dietary non-nutrients with chemopreventive properties
| Autor: | Arnold Stern, Harvey Babich, Ellen Borenfreund |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Mice
Inbred BALB C Cancer Research Phenethyl isothiocyanate Plant Extracts Vanillin 3T3 Cells Saccharic acid Flavoring Agents Kinetics Mice chemistry.chemical_compound Oncology Biochemistry chemistry Benzaldehydes Tannic acid Caffeic acid Animals Anticarcinogenic Agents Cytotoxicity Quercetin Ellagic acid |
| Zdroj: | Cancer Letters. 73:127-133 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(93)90254-7 |
| Popis: | The comparative acute cytotoxicities were determined for a varied spectrum of minor dietary non-nutrients that have been implicated as chemopreventive agents. Cytotoxicity was determined with the neutral red (NR) assay, using BALB/c mouse 3T3 fibroblasts as the bioindicators. Based on midpoint cytotoxicity (NR50) values, the range of cytotoxicity for the different chemicals varied by 1000 times. The sequence of potency was tannic acid, tamoxifen citrate, quercetin, benzyl and phenethyl isothiocyanate>glycyrrhetinic acid>indole-3-carbinol>caffeic acid>phytic acid>vanillin>ellagic acid> d -saccharic acid 1,4-lactone. Vanillin, at slight to moderately toxic concentrations, was the only test agent that induced multinucleation in the 3T3 fibroblasts. |
| Databáze: | OpenAIRE |
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