A rare initial presentation of gastric cancer with multiple osteolytic lesions
| Autor: | Sharon Swierczynski, Anam Qureshi, Oluwaseun Shogbesan, Priya Rajagopalan, Christian Espana Schmidt, Kim Aderhold, Qasim Jehangir, Asad Jehangir |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Esophagogastroduodenoscopy Signet ring cell Cancer Case Report lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease lcsh:RC254-282 digestive system diseases Surgery Elevated alkaline phosphatase Capecitabine Oncology Biopsy medicine Radiology Headaches medicine.symptom business Complication medicine.drug |
| Zdroj: | Case Reports in Oncological Medicine Case Reports in Oncological Medicine, Vol 2015 (2015) |
| ISSN: | 2090-6706 |
| Popis: | Gastric cancer is the 12th leading cause of cancer-related deaths in the United States and commonly metastasizes to the bones. However, the presentation of gastric cancer as bony metastases without preceding gastrointestinal symptoms is rare which has been infrequently reported in the literature. Moreover, leptomeningeal carcinomatosis is an unusual complication of gastric cancer accounting for less than 1 percent of these patients. We present a unique case of a middle aged male who presented to the emergency department with worsening backache which started one month priorly. The only abnormal laboratory test was an elevated alkaline phosphatase of 154 IU/L. The imaging of his spine showed osteolytic lesions which on biopsy revealed signet ring cells. A small 2 cm ulcerated mass was found on esophagogastroduodenoscopy at the gastric cardia which on biopsy revealed signet ring gastric carcinoma. The patient received chemotherapy with capecitabine and oxaliplatin as well as radiation and showed a good response initially. A few months later, he presented with persistent worsening headaches and on brain imaging was found to have leptomeningeal carcinomatosis. Ten months after the diagnosis of gastric carcinoma, he passed away. |
| Databáze: | OpenAIRE |
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