Cigarette smoke toxins deposited on surfaces: implications for human health

Autor: Monika Garcia, Laura A. Gundel, Benjamin Goodwin, Hugo Destaillats, Sandy Liles, Jonathan P. Winickoff, Sandeep Dhall, Lisa Yu, Christopher Havel, Neal L. Benowitz, Manuela Martins-Green, Michael Frankos, Mathew Valdez, Bethanne Martinez, Ivie Egiebor, Harry W. Green, Neema Adhami, Melbourne F. Hovell, Georg E. Matt, Peyton Jacob, Mohammed Sleiman, Julia G. Lyubovitsky, Margarita C. Currás-Collazo
Rok vydání: 2013
Předmět:
Pathology
Cirrhosis
Pyridines
Pulmonary Fibrosis
Physiology
lcsh:Medicine
Disease
Cardiovascular
Global Health
Toxicology
Third-hand smoke
Mice
0302 clinical medicine
Fibrosis
Non-alcoholic Fatty Liver Disease
Pulmonary fibrosis
Molecular Cell Biology
030212 general & internal medicine
lcsh:Science
Lung
Psychomotor Agitation
Skin
0303 health sciences
Multidisciplinary
Systems Biology
Fatty liver
3. Good health
Liver
Child
Preschool
Medicine
Collagen
Research Article
medicine.medical_specialty
Nitrosamines
Histology
03 medical and health sciences
medicine
Animals
Humans
Maze Learning
Biology
030304 developmental biology
Asthma
Smoke
Wound Healing
business.industry
lcsh:R
Infant
medicine.disease
Fatty Liver
Mice
Inbred C57BL
Metabolic Disorders
lcsh:Q
Tobacco Smoke Pollution
business
Biomarkers
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e86391 (2014)
ISSN: 1932-6203
Popis: Cigarette smoking remains a significant health threat for smokers and nonsmokers alike. Secondhand smoke (SHS) is intrinsically more toxic than directly inhaled smoke. Recently, a new threat has been discovered – Thirdhand smoke (THS) – the accumulation of SHS on surfaces that ages with time, becoming progressively more toxic. THS is a potential health threat to children, spouses of smokers and workers in environments where smoking is or has been allowed. The goal of this study is to investigate the effects of THS on liver, lung, skin healing, and behavior, using an animal model exposed to THS under conditions that mimic exposure of humans. THS-exposed mice show alterations in multiple organ systems and excrete levels of NNAL (a tobacco-specific carcinogen biomarker) similar to those found in children exposed to SHS (and consequently to THS). In liver, THS leads to increased lipid levels and non-alcoholic fatty liver disease, a precursor to cirrhosis and cancer and a potential contributor to cardiovascular disease. In lung, THS stimulates excess collagen production and high levels of inflammatory cytokines, suggesting propensity for fibrosis with implications for inflammation-induced diseases such as chronic obstructive pulmonary disease and asthma. In wounded skin, healing in THS-exposed mice has many characteristics of the poor healing of surgical incisions observed in human smokers. Lastly, behavioral tests show that THS-exposed mice become hyperactive. The latter data, combined with emerging associated behavioral problems in children exposed to SHS/THS, suggest that, with prolonged exposure, they may be at significant risk for developing more severe neurological disorders. These results provide a basis for studies on the toxic effects of THS in humans and inform potential regulatory policies to prevent involuntary exposure to THS.
Databáze: OpenAIRE
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