Large-scale resculpting of cortical circuits in children after surgical resection
| Autor: | Michael Granovetter, Daniel R. Glen, Christina Patterson, Erez Freud, Mark A. Pinsk, Anne Margarette S. Maallo, Marlene Behrmann, Sabine Kastner |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Surgical resection Cortical circuits Multidisciplinary Science Biology Mutually exclusive events Cortical volume Article Resection Correlation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neurology Cortical resection Medicine Surgical treatment Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection. |
| Databáze: | OpenAIRE |
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