Giant Cell Tumor of Bone Without Giant Cells with a Long Clinical Course: A Case Report

Autor:	Hiroki Takase, Ikuma Kato, Junko Ito, Yusuke Kawabata, Tetsuhiko Okabe, Masanobu Takeyama, Satoshi Fujii
Rok vydání:	2022
Předmět:	Surgery Anatomy Pathology and Forensic Medicine
Zdroj:	International Journal of Surgical Pathology. 31:190-194
ISSN:	1940-2465 1066-8969
DOI:	10.1177/10668969221098090
Popis:	Giant cell tumor of bone (GCTB) consists of a mixture of neoplastic mononuclear cells and non-neoplastic cells, including polynuclear giant cells. Recently, with the spread of the immunohistochemical staining marker H3.3 G34W corresponding to specific genetic abnormalities, the histological diversity of GCTB has been recognized. GCTB without giant cells is uncommon, although it has also been reported previously. Herein, we describe a 45-year-old man with GCTB without giant cells who was successfully diagnosed using H3.3 G34W immunohistochemistry. Other unusual findings in GCTB that were identified in this patient include bone and osteoid formation with a long clinical course of 13 years. We also compared the histological findings of the current patient to those who received denosumab therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fc72455689c0e4cff8c26b830b4ef4 https://doi.org/10.1177/10668969221098090 Zobrazit plný text záznamu