Lumpectomy Plus Tamoxifen or Anastrozole With or Without Whole Breast Irradiation in Women With Favorable Early Breast Cancer
| Autor: | Friedrich Hofbauer, Michael Stierer, G. Luschin-Ebengreuth, Karin S. Kapp, Leonore Handl-Zeller, Susanne Taucher, G. Reiner, Michael Gnant, Christoph Tausch, Felix Sedlmayer, Karin Haider, B. Pakisch, Sabine Pöstlberger, Raimund Jakesz, Richard Pötter, Andrea Rottenfusser, W. Draxler, Werner Kwasny, Marianne Schmid, Josef Hammer |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Antineoplastic Agents Hormonal medicine.medical_treatment Anastrozole Breast Neoplasms Mastectomy Segmental Whole Breast Irradiation Internal medicine Nitriles medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies skin and connective tissue diseases Survival rate Aged Aged 80 and over Radiation business.industry Lumpectomy Hazard ratio Radiotherapy Dosage Middle Aged Triazoles Survival Rate Radiation therapy Tamoxifen Female Neoplasm Recurrence Local business Mastectomy medicine.drug |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 68:334-340 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2006.12.045 |
| Popis: | In women with favorable early breast cancer treated by lumpectomy plus tamoxifen or anastrazole, it remains unclear whether whole breast radiotherapy is beneficial.Between January 1996 and June 2004, the Austrian Breast and Colorectal Cancer Study Group (ABCSG) randomly assigned 869 women to receive breast radiotherapy +/- boost (n = 414) or not (n = 417) after breast-conserving surgery (ABCSG Study 8A). Favorable early breast cancer was specified as tumor size3 cm, Grading 1 or 2, negative lymph nodes, positive estrogen and/or progesterone receptor status, and manageable by breast-conserving surgery. Breast radiotherapy was performed after lumpectomy with 2 tangential opposed breast fields with mean 50 Gy, plus boost in 71% of patients with mean 10 Gy, in a median of 6 weeks. The primary endpoint was local relapse-free survival; further endpoints were contralateral breast cancer, distant metastases, and disease-free and overall survival. The median follow-up was 53.8 months.The mean age was 66 years. Overall, there were 21 local relapses, with 2 relapses in the radiotherapy group (5-y rate 0.4%) vs. 19 in the no-radiotherapy group (5.1%), respectively (p = 0.0001, hazard ratio 10.2). Overall relapses occurred in 30 patients, with 7 events in the radiotherapy group (5-y rate 2.1%) vs. 23 events in the no-radiotherapy group (6.1%) (p = 0.002, hazard ratio 3.5). No significant differences were found for distant metastases and overall survival.Breast radiotherapy +/- boost in women with favorable early breast cancer after lumpectomy combined with tamoxifen/anastrazole leads to a significant reduction in local and overall relapse. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|