An innovative and eco-friendly modality for synthesis of highly fluorinated graphene by an acidic ionic liquid: Making of an efficacious vehicle for anti-cancer drug delivery

Autor: Vahid Haddadi-Asl, Elaheh Kowsari, Firoz Babu Kadumudi, Jong Hyun Lee, Alireza Dolatshahi-Pirouz, Mehdi Mehrali, Meysam Aryafard, Nazila Kamaly, Sepehr Talebian, Behrouz Bazri, Mohammadjavad Jahanshahi, Mehdi Khoobi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Fluorinated graphene
Curcumin loading efficiency
General Physics and Astronomy
Salt (chemistry)
chemistry.chemical_element
Ammonium fluoride
02 engineering and technology
Ionic liquid
010402 general chemistry
01 natural sciences
law.invention
Nanomaterials
chemistry.chemical_compound
All institutes and research themes of the Radboud University Medical Center
SDG 3 - Good Health and Well-being
law
Mild-temperature fluorination
SDG 13 - Climate Action
Cancer drug delivery
chemistry.chemical_classification
Graphene
Surfaces and Interfaces
General Chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Combinatorial chemistry
0104 chemical sciences
Surfaces
Coatings and Films
Solvent
Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]
chemistry
Fluorine
Nanocarriers
0210 nano-technology
Eco-friendly synthesis
Zdroj: Jahanshahi, M, Kowsari, E, Haddadi-Asl, V, Khoobi, M, Bazri, B, Aryafard, M, Lee, J H, Kadumudi, F B, Talebian, S, Kamaly, N, Mehrali, M & Dolatshahi-Pirouz, A 2020, ' An innovative and eco-friendly modality for synthesis of highly fluorinated graphene by an acidic ionic liquid: Making of an efficacious vehicle for anti-cancer drug delivery ', Applied Surface Science, vol. 515, 146071 . https://doi.org/10.1016/j.apsusc.2020.146071
Applied Surface Science, 515
ISSN: 0169-4332
DOI: 10.1016/j.apsusc.2020.146071
Popis: Fluorination of graphene nanomaterials has multitude merits owing to the peculiar temperament of the carbon-fluorine (C-F) bond. However, the current synthesis modalities of fluorinated graphene (FG) are based on the usage of toxic materials at high temperatures, which are problematic to be used. The methods to overcome these problems are challenging for chemists. Ionic liquids (ILs) have been used in several chemical processes as auxiliaries and eco-friendly alternatives instead of volatile organic solvents because of their properties. Consequently, herein we exploited a highly effective and green process for the synthesis of FG at mild temperature (80 °C) by using ammonium fluoride salt as fluorine agent and a synthesized acidic IL ([TEA]+[TFA]–) as a solvent. Our goal was to synthesize enriched FG with a high degree of fluorination (66.4 wt.% of F) and F/C ratio (2.2), which measured and confirmed by XPS analysis. Subsequently, the obtained FG was used as a nanocarrier for delivery of curcumin to cancerous cells. The in-vitro results showed that these nanosheets possessed a higher Cur-loading efficiency (78.43%) than commercial FG (52.12%) due to the sheet-like structure with folded edges. This, in turn, translated into an excellent in-vitro anti-cancer effect when tested against cancerous cells.
Databáze: OpenAIRE
Externí odkaz: