Peroxisome proliferator-activated receptor gamma coactivator 1α variation: a closer look at obesity onset age and its related metabolic status and body composition
| Autor: | Seyed Ali Keshavarz, Negar Zamaninour, Khadijeh Mirzaei, Zhila Maghbooli |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Peroxisome proliferator-activated receptor Biology Polymorphism Single Nucleotide Young Adult 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine Coactivator medicine Humans Lack of knowledge Obesity 030212 general & internal medicine Age of Onset Receptor Gene chemistry.chemical_classification Nutrition and Dietetics General Medicine Middle Aged Peroxisome medicine.disease Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Cross-Sectional Studies 030104 developmental biology Endocrinology chemistry Body Composition Female Age of onset |
| Zdroj: | Applied Physiology, Nutrition, and Metabolism. 43:1321-1325 |
| ISSN: | 1715-5320 1715-5312 |
| DOI: | 10.1139/apnm-2018-0190 |
| Popis: | There is a lack of knowledge regarding the effect of polymorphisms of the peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α) gene on the age of obesity onset. Hence, 3 polymorphisms of the PGC-1α gene (PGC-1α rs17574213, rs8192678, and rs3755863) were examined in association with obesity onset age. Also, obesity onset age-related metabolic status and body composition were evaluated. This cross-sectional study was conducted with a total of 321 obese participants. Anthropometric and biochemical information, body composition, and PGC-1α gene sequences were analyzed. The rs17574213 polymorphism was associated with obesity onset in children aged |
| Databáze: | OpenAIRE |
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