Optical coherent tomographic angiographic pattern of the deep choroidal layer and choriocapillaris after photodynamic therapy for central serous chorioretinopathy
| Autor: | Wen Bin Wei, Jost B. Jonas, Xue Hui Shi, Qian Wang, Szy Yann Chan, Chung Ting Pan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine 030103 biophysics medicine.medical_specialty Fundus Oculi medicine.medical_treatment Visual Acuity Photodynamic therapy 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Ophthalmology Reference level medicine Humans Prospective Studies Fluorescein Angiography Photosensitizing Agents Kappa value Choroid business.industry Retinal Vessels Verteporfin Mean age Optical coherence tomography angiography Middle Aged eye diseases Sensory Systems Capillaries Serous fluid medicine.anatomical_structure Central Serous Chorioretinopathy Photochemotherapy 030221 ophthalmology & optometry Female sense organs business Tomography Optical Coherence Follow-Up Studies |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 257:1365-1372 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-019-04318-x |
| Popis: | To study the changes in the choroidal vascular pattern of the deep choroidal layer and choriocapillaris in the eyes with central serous chorioretinopathy (CSC) before versus after photodynamic therapy (PDT) as visualized by optical coherence tomography angiography (OCTA). This comparative case series study included patients who underwent a half-dose of PDT as a therapy for CSC. Using OCTA and manually shifting the reference level into the deep choroidal layer, we assessed the density of the deep choroidal vascular layer and choriocapillaris. The study included 20 patients (17 men; mean age, 43.3 ± 10.9 years), with two patients showing bilateral CSC. In the eyes affected by CSC, the mean vascular density of the deep choroidal layer and choriocapillaris increased significantly from 54.2 ± 6.7% at baseline to 58.0 ± 4.7% at 1 month after PDT (P = 0.002) and from 58.1 ± 2.7% at baseline to 60.5 ± 2.7% at 1 month after PDT (P = 0.004), respectively. The difference between affected and unaffected eyes was significantly larger at baseline than at 1 month after PDT (deep choroidal layer 4.79 ± 6.02 versus 0.39 ± 3.46, P = 0.002; choriocapillaris 4.26 ± 3.94 versus 1.25 ± 3.44, P = 0.002) and larger than at 3 months after baseline (n = 11 patients), when the affected and unaffected fellow eyes no longer differed significantly (P = 0.66 and P = 0.37, respectively). As a corollary, the width of the large choroidal vessels in the deep choroidal layer decreased after the PDT. Comparing assessments by two blinded examiners revealed a kappa value of 0.90, indicating a good agreement for examination of the deep choroidal layer. In conclusion, OCTA can be helpful to visualize the deep choroidal vascular layer by manually shifting the reference layer deeper into the choroid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink