Assessing the Therapeutic Use of Lafoensia pacari St. Hil. Extract (Mangava-Brava) in the Eradication of Helicobacter pylori: Double-Blind Randomized Clinical Trial
| Autor: | Wilson R. Catapani, Álvaro Nagib Atallah, Antonio José Lapa, Valfredo da Mota Menezes |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Antibiotics Population Placebo Helicobacter Infections Persistence (computer science) law.invention Double-Blind Method Randomized controlled trial law Internal medicine medicine Humans Lafoensia pacari Dyspepsia education Aged Lythraceae education.field_of_study Helicobacter pylori biology Plant Extracts business.industry Gastroenterology General Medicine Middle Aged biology.organism_classification Surgery Clinical trial Treatment Outcome Infectious Diseases Female business |
| Zdroj: | Helicobacter. 11:188-195 |
| ISSN: | 1523-5378 1083-4389 |
| DOI: | 10.1111/j.1523-5378.2006.00399.x |
| Popis: | Background: The eradication of Helicobacter pylori is easily achieved by combining antisecretory agents and antibiotics; however, the cost of these associations is very high for the population of Third World countries, where the prevalence of the infection is even higher and leads to markedly reduced treatment effectiveness. We tested a plant (Lafoensia pacari) that is used in the central region of Brazil. According to previous studies, this plant has high concentrations of ellagic acid, which presents gastric antisecretory and antibacterial actions. Material and Methods: One hundred dyspeptic, urease-positive patients were randomized to receive 500 mg of methanolic extract of L. pacari (n = 55) or placebo (n = 45), for 14 days, in a double-blind clinical trial. The main variables assessed were the eradication of H. pylori 8 weeks after the intervention and complete symptom relief at the end of the treatment. Results: The examinations (urease and histology) showed persistence of H. pylori in 100% of participants. Complete symptom relief was experienced by 42.5% of patients (95% CI: 29.4–55.8) in the intervention group and by 21% (95% CI: 8.8–33.1) in the control group, p = .020. The side-effects were minimal and similar in both groups. Conclusions: The extract of L. pacari as a single agent was not effective to eradicate H. pylori. However, it was well tolerated and many participants reported relief of symptoms. Future studies may test the agent using larger doses and longer periods, in monotherapy or in combination with antibiotics. |
| Databáze: | OpenAIRE |
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