Microscale plasma-initiated patterning of electrospun polymer scaffolds
| Autor: | Christopher L. Ricupero, Jeremy Griffin, Martin Grumet, Kathryn E. Uhrich, Sally Meiners, Roberto Delgado-Rivera |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Materials science
Polymers Surface Properties Nanotechnology Substrate (printing) Article Plasma chemistry.chemical_compound Colloid and Surface Chemistry Cell Adhesion Animals Dimethylpolysiloxanes Physical and Theoretical Chemistry Microscale chemistry chemistry.chemical_classification Polydimethylsiloxane Biomolecule Surfaces and Interfaces General Medicine Polymer Rats chemistry Nanofiber Polyamide Microscopy Electron Scanning Laminin Biotechnology Micropatterning |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 84:591-596 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2011.01.014 |
| Popis: | Microscale plasma-initiated patterning (μPIP) is a novel micropatterning technique used to create biomolecular micropatterns on polymer surfaces. The patterning method uses a polydimethylsiloxane (PDMS) stamp to selectively protect regions of an underlying substrate from oxygen plasma treatment resulting in hydrophobic and hydrophilic regions. Preferential adsorption of the biomolecules onto either the plasma-exposed (hydrophilic) or plasma-protected (hydrophobic) regions leads to the biomolecular micropatterns. In the current work, laminin-1 was applied to an electrospun polyamide nanofibrillar matrix following plasma treatment. Radial glial clones (neural precursors) selectively adhered to these patterned matrices following the contours of proteins on the surface. This work demonstrates that textured surfaces, such as nanofibrillar scaffolds, can be micropatterned to provide external chemical cues for cellular organization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect