Adult body height and age-related macular degeneration in healthy individuals: A nationwide population-based survey from Korea

Autor: In Cheol Hwang, Joon Mo Kim, Jeong Hun Bae, Quan Dong Nguyen, Jung Min Lee
Rok vydání: 2020
Předmět:
Male
genetic structures
Physiology
Logistic regression
Body Mass Index
Macular Degeneration
0302 clinical medicine
Risk Factors
Medicine and Health Sciences
Medicine
Public and Occupational Health
030212 general & internal medicine
Geriatric Ophthalmology
education.field_of_study
Alcohol Consumption
Multidisciplinary
Retinal Degeneration
Age Factors
Ophthalmic Procedures
Cataract Surgery
Middle Aged
Physiological Parameters
Retinal Disorders
Female
Anatomy
Research Article
Adult
National Health and Nutrition Examination Survey
Science
Population
Surgical and Invasive Medical Procedures
03 medical and health sciences
Ocular System
Republic of Korea
Humans
Obesity
education
Aged
Nutrition
business.industry
Body Weight
Biology and Life Sciences
Physical Activity
Odds ratio
Macular degeneration
medicine.disease
Body Height
eye diseases
Confidence interval
Diet
Ophthalmology
Cross-Sectional Studies
Geriatrics
Macular Disorders
030221 ophthalmology & optometry
Eyes
sense organs
business
Head
Body mass index
Demography
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0232593 (2020)
ISSN: 1932-6203
Popis: We sought to evaluate the relationship between adult body height and risk of age-related macular degeneration (AMD) among healthy Koreans using nationwide population-based data. We analyzed data derived from the Korea National Health and Nutrition Examination Survey 2008-2011. Participants over 40 years of age were included in the sample after excluding individuals with systemic comorbidities or missing relevant data. The presence and severity of AMD were graded using fundus photographs. The relationship between body height and risk of AMD was determined using multiple logistic regression analyses. Among a total of 8,435 participants, 544 (6.45%) had AMD: 502 (5.95%) with early AMD and 42 (0.5%) with late AMD. In multivariate-adjusted analyses, taller body height was significantly associated with a lower prevalence of AMD (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.81-0.99), while body mass index (BMI) was not associated with AMD. An inverse association between body height and risk of AMD was observed most frequently in participants under 65 years of age (OR, 0.81; 95% CI, 0.70-0.94). Furthermore, body height showed an inverse association with risk of AMD among obese participants (BMI ≥25.0 kg/m2) (OR, 0.75; 95% CI, 0.60-0.93). Subgroup analysis by AMD type disclosed a significant inverse association between body height and early AMD (OR, 0.87; 95% CI, 0.79-0.97) but not late AMD. Our results suggest that shorter body height is independently associated with increased risk of AMD, especially early AMD, in a dose-response manner in people who are obese or under 65 years of age.
Databáze: OpenAIRE
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