Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
| Autor: | Charu Ramakrishnan, Yoon Seok Kim, Lydia-Marie Joubert, Karl Deisseroth, Kang Shen, Ariane Tom, Jeffrey B.-H. Tok, Huiliang Wang, Yuanwen Jiang, Shucheng Chen, Claire E. Richardson, Xiao Wang, Cheng Wang, Sergiu P. Pașca, Toru Katsumata, Jia Liu, Zhenan Bao, Lief E. Fenno, Fikri Birey |
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| Rok vydání: | 2020 |
| Předmět: |
Patch-Clamp Techniques
Cell Survival Polymers Cell Action Potentials 02 engineering and technology Phenylenediamines Hippocampus Membrane Potentials Synthetic materials Mice 03 medical and health sciences Transduction (genetics) Ascorbate Peroxidases Transduction Genetic medicine Animals Humans Caenorhabditis elegans Cells Cultured 030304 developmental biology Motor Neurons Neurons Muscle Cells 0303 health sciences Aniline Compounds Multidisciplinary biology Chemistry Cell Membrane HEK 293 cells Electric Conductivity Nitro Compounds 021001 nanoscience & nanotechnology biology.organism_classification Rats Living systems Cell biology Multicellular organism HEK293 Cells medicine.anatomical_structure Functional polymers Genetic Engineering 0210 nano-technology |
| Zdroj: | Science. 367:1372-1376 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | From genetics to material to behavior Introducing new genes into an organism can endow new biochemical functions or change the patterns of existing functions, but extending these manipulations to structure at the tissue level is challenging. Combining genetic engineering and polymer chemistry, Liu et al. directly leveraged complex cellular architectures of living organisms to synthesize, fabricate, and assemble bioelectronic materials (see the Perspective by Otto and Schmidt). An engineered enzyme expressed in genetically targeted neurons synthesized conductive polymers in tissues of freely moving animals. These polymers enabled modulation of membrane properties in specific neuron populations and manipulation of behavior in living animals. Science , this issue p. 1372 ; see also p. 1303 |
| Databáze: | OpenAIRE |
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