The MR detection of neuronal depolarization during 3-Hz spike-and-wave complexes in generalized epilepsy
| Autor: | Adam D. Liston, Robert Turner, Khalid Hamandi, Stefan J. Kiebel, Louis Lemieux, Afraim Salek-Haddadi |
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| Rok vydání: | 2004 |
| Předmět: |
Biomedical Engineering
Biophysics Signal Idiopathic generalized epilepsy Nuclear magnetic resonance Thalamus Image Processing Computer-Assisted medicine Humans Premovement neuronal activity Radiology Nuclear Medicine and imaging Generalized epilepsy Evoked Potentials Cerebral Cortex Neurons Physics medicine.diagnostic_test Echo-Planar Imaging Spike-and-wave Electroencephalography Magnetic resonance imaging Depolarization Image Enhancement medicine.disease Magnetic Resonance Imaging Frontal Lobe Oxygen Epilepsy Generalized Functional magnetic resonance imaging |
| Zdroj: | Magnetic Resonance Imaging. 22:1441-1444 |
| ISSN: | 0730-725X |
| Popis: | Previously, an analysis of activations observed in a patient with idiopathic generalized epilepsy using electroencephalogram-correlated functional magnetic resonance imaging (MRI) during runs of 3-Hz generalized spike-wave discharge (GSWD) was presented by Salek-Haddadi. Time-locked, bilateral, thalamic blood oxygenation level-dependent increases were reported to be accompanied by widespread, symmetric, cortical deactivation with a frontal maximum. In light of recent investigations into MRI detection of the magnetic field perturbations caused by neuronal current loops during depolarization, we revisited the analysis of the data of Salek-Haddadi as a preliminary search for a neuroelectric signal. We modeled the MRI response as the sum of a fast signal and a slower signal and demonstrated significant MRI activity at a time scale of the order of 30 ms associated with GSWDs. Further work is necessary before firm conclusions may be drawn about the nature of this signal. |
| Databáze: | OpenAIRE |
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