Obtaining hesperetin 7-O-glucosyl 6’’-O-laurate, a high lipophilic flavonoid ester, from Citrus waste
| Autor: | Gustavo Celiz, Ramón Díaz, Mirta Elizabeth Daz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Flavonoid NEOHESPERIDIN Bioengineering INGENIERÍAS Y TECNOLOGÍAS 01 natural sciences Applied Microbiology and Biotechnology Biotecnología Industrial 03 medical and health sciences chemistry.chemical_compound Hydrolysis 010608 biotechnology Moiety Organic chemistry ENZYMATIC ESTERIFICATION Solubility HESPERETIN 7-O-GLUCOSIDE Neohesperidin chemistry.chemical_classification purl.org/becyt/ford/2.9 [https] Hesperetin FLAVONOID ESTER CITRUS PROCESSING WASTE 030104 developmental biology purl.org/becyt/ford/2 [https] chemistry Biocatalysis Lipophilicity Agronomy and Crop Science Food Science Biotechnology |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | A biotechnological process that combines the treatment of Citrus processing waste to extract a high-valuable biomolecule, neohesperidin (NEO), and its further modification by biocatalysis to enhance the lipophilicity of its flavonoic moiety is presented. NEO was extracted from immature fruits of Citrus aurantium and hydrolyzed by a commercial alpha-rhamnosidase to obtain hesperetin 7-glucoside (HG). NEO and HG were mono-acylated with vinyl laurate by using Novozym 435 in their primary OH-groups, but the esterification reaction was substantially faster for HG than NEO. Furthermore, the activation energy of the reaction lowers as solvents’ log-P decreases linearly. Under best conditions, HGL was obtained at gram scale with a simple downstream process. The solubility in n-octanol increased with each biocatalytic step (NEO Fil: Celiz, Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina Fil: Díaz, Ramón. Universidad Nacional de Salta. Facultad de Ciencias Exactas. Departamento de Química; Argentina Fil: Daz, Mirta Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina |
| Databáze: | OpenAIRE |
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