Is HPV the Novel Target in Male Idiopathic Infertility? A Systematic Review of the Literature

Autor: Andrea Carosso, Andrea Garolla, Carlo Foresta, Francesco Muscianisi, Luca De Toni, Gloria Giorato
Rok vydání: 2020
Předmět:
0301 basic medicine
Infertility
Male
Pediatrics
medicine.medical_specialty
media_common.quotation_subject
Endocrinology
Diabetes and Metabolism
Idiopathic infertility
Sexually Transmitted Diseases
Fertility
Comorbidity
Review
In Vitro Techniques
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Hypothalamic disease
Asymptomatic
Antibodies
male infertility
Male infertility
03 medical and health sciences
0302 clinical medicine
Endocrinology
Semen
medicine
Animals
Humans
human papillomavirus
Papillomaviridae
Infertility
Male
media_common
lcsh:RC648-665
030219 obstetrics & reproductive medicine
business.industry
Papillomavirus Infections
HPV infection
HPV treatment
medicine.disease
Spermatozoa
HPV seminal infection
030104 developmental biology
Etiology
assisted reproductive technique
anti-sperm antibodies
Female
medicine.symptom
business
Zdroj: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
ISSN: 1664-2392
Popis: Infertility is an important health problem that affects up to 16% of couples worldwide. Male infertility is responsible for about 50% of the cases, and the various causes of male infertility may be classified in pre-testicular (for example hypothalamic diseases), testicular, and post-testicular (for example obstructive pathologies of seminal ducts) causes. Sexually transmitted infections (STI) are increasingly widely accepted by researchers and clinicians as etiological factors of male infertility. In particular, several recent reports have documented the presence of HPV in seminal fluid and observed that sperm infection can also be present in sexually active asymptomatic male and infertile patients. In this review, we aimed to perform a systematic review of the whole body of literature exploring the impact of HPV infection in natural and assisted fertility outcomes, from both an experimental and a clinical point of view. Starting from in-vitro studies in animals up to in-vivo studies in humans, we aimed to study and evaluate the weight of this infection as a possible cause of idiopathic infertility in males with any known cause of conception failure.
Databáze: OpenAIRE
Externí odkaz: