In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
| Autor: | Dean L. Shinabarger, Chris M. Pillar, Cindy Wolfe, Laure Stapert, Andrea Marra |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology biology Chemistry 030106 microbiology omadacycline anaerobes Porphyromonas Tigecycline Clinical Therapeutics Clostridium perfringens Clostridium difficile biology.organism_classification medicine.disease_cause Peptostreptococcus Microbiology 03 medical and health sciences Infectious Diseases medicine Prevotella Pharmacology (medical) Anaerobic bacteria Bacteroides medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Omadacycline (OMC), a broad-spectrum aminomethylcycline, has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections. Here, the in vitro activity of OMC against clinically relevant anaerobes was similar to that of tigecycline, with MIC 90 values of 1 to 8 μg/ml against Bacteroides spp., 0.5 μg/ml against Clostridium difficile , Prevotella spp., and Porphyromonas asaccharolytica , 1 μg/ml against Peptostreptococcus spp., and 16 μg/ml against Clostridium perfringens . |
| Databáze: | OpenAIRE |
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