Sialyltransferase: A novel acute-phase reactant
| ISSN: | 0305-0491 |
|---|---|
| DOI: | 10.1016/0305-0491(93)90165-2 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ee69ae70fc0c901453b3a5485c8300 https://doi.org/10.1016/0305-0491(93)90165-2 |
| Rights: | CLOSED |
| Přírůstkové číslo: | edsair.doi.dedup.....90ee69ae70fc0c901453b3a5485c8300 |
| Autor: | P.G. Harder, J.C. Jamieson, G. McCaffrey |
| Rok vydání: | 1993 |
| Předmět: |
Physiology
Sialyltransferase Gene Expression Golgi Apparatus Inflammation Biochemistry chemistry.chemical_compound symbols.namesake Biosynthesis Gene expression medicine Animals beta-D-Galactoside alpha 2-6-Sialyltransferase Molecular Biology chemistry.chemical_classification biology Acute-phase protein General Medicine Golgi apparatus Sialyltransferases Enzyme Liver chemistry biology.protein symbols medicine.symptom Glycoprotein Acute-Phase Proteins |
| Zdroj: | Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 105:29-33 |
| ISSN: | 0305-0491 |
| DOI: | 10.1016/0305-0491(93)90165-2 |
| Popis: | 1. Proteins that are released into the circulation in elevated amounts in injured mammals are referred to as acute-phase reactants. Most are liver synthesized glycoproteins of the secretable type. However, Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase (EC 2.4.99.1) is a novel acute-phase reactant since it is a Golgi membrane-bound enzyme rather than a secretable glycoprotein. 2. The role of glucocorticoids and cytokines in the control of synthesis and expression of acute-phase glycoproteins, including sialyltransferase, is discussed. 3. The acute-phase behaviour of Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase is dependent on the release of the enzyme from the Golgi in the acute-phase state. The mechanism of release of a catalytically active form of the enzyme is described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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