Cocaine induction of ERK proteins in dorsal striatum of Fischer rats
| Autor: | Vanya Quinones-Jenab, Shirzad Jenab, Ruhal Hazim, Arbi Nazarian, Eugene D. Festa, Hui Bing K. Wu, Wei-Lun Sun, Scott J. Russo |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Blotting Western Electrophoretic Mobility Shift Assay Striatum Biology Cellular and Molecular Neuroscience chemistry.chemical_compound Eticlopride Dopamine receptor D1 Cocaine Dopamine Uptake Inhibitors Dopamine Internal medicine Salicylamides Basal ganglia medicine Animals Drug Interactions Phosphorylation Cyclic AMP Response Element-Binding Protein Neurotransmitter Molecular Biology Dose-Response Relationship Drug Putamen Benzazepines Corpus Striatum Rats Inbred F344 Rats Endocrinology Gene Expression Regulation chemistry Dopamine receptor Enzyme Induction Dopamine Antagonists Dizocilpine Maleate Mitogen-Activated Protein Kinases Excitatory Amino Acid Antagonists medicine.drug |
| Zdroj: | Molecular Brain Research. 142:134-138 |
| ISSN: | 0169-328X |
| Popis: | Cocaine is an addictive psychostimulant that induces fos and opioid gene expression by activating the dopamine receptors and the PKA pathways in dopamine D1 and a glutamate NMDA-dependent mechanisms in the striatum. In this study, we show that a single cocaine administration induces ERK phosphorylation in the caudate/putamen of Fischer rats. This increase in Phospho-ERK is diminished by pre-administration of SCH23390, or MK801 but not with pre-administration of eticlopride. Furthermore, this single cocaine administration does not alter the levels of phospho-CREB protein or CREB-DNA bindings in the caudate/putamen protein extracts but does increase phospho-Elk-1 protein levels in the same extracts. |
| Databáze: | OpenAIRE |
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