Intracellular routes of a lysosome marker enzyme, acid phosphatase, in proximal convoluted tubule cells of human kidney in glomerulonephritis as studied by electron cytochemistry
| Autor: | Plotkin VYa, Nevorotin Aj, Ryabov Si |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male Adolescent Biopsy Acid Phosphatase Vacuole Kidney Kidney Tubules Proximal symbols.namesake Glomerulonephritis Lysosome medicine Humans biology Histocytochemistry Acid phosphatase Golgi apparatus medicine.disease Cell biology medicine.anatomical_structure Convoluted tubule Cytochemistry symbols biology.protein Female Lysosomes Intracellular |
| Zdroj: | Nephron. 29(1-2) |
| ISSN: | 1660-8151 |
| Popis: | Localization of acid phosphatase (AcPase) in proximal convoluted tubule (PT) cells obtained from human kidney biopsies of 25 patients with glomerulonephritis was studied by electron microscopy. AcPase activity was detected in the Golgi apparatus, GERL, microvesicles and cytosomes. Evidence suggestive of the fusion between AcPase-positive bodies and large apical vacuoles was seen, and release of AcPase into the lumen and basal membrane of PT cells sometimes encountered. The possible significance of this phenomenon is discussed. |
| Databáze: | OpenAIRE |
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