Incremental clinical effectiveness and cost effectiveness of providing supervised physiotherapy in addition to usual medical care in patients with osteoarthritis of the hip or knee: 2-year results of the MOA randomised controlled trial
Autor: | JHaxby Abbott, Ross Wilson, Alexis A. Wright, Cathy Chapple, Daniel Pinto |
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Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty WOMAC Cost effectiveness Cost-Benefit Analysis Biomedical Engineering Osteoarthritis Medical care Osteoarthritis Hip law.invention 03 medical and health sciences 0302 clinical medicine Rheumatology Randomized controlled trial law Internal medicine medicine Humans Orthopedics and Sports Medicine Adverse effect Physical Therapy Modalities Aged 030203 arthritis & rheumatology business.industry Osteoarthritis Knee medicine.disease Combined Modality Therapy Exercise Therapy Clinical trial Treatment Outcome 030104 developmental biology Physical therapy Female business |
Zdroj: | Osteoarthritis and Cartilage. 27:424-434 |
ISSN: | 1063-4584 |
Popis: | Summary Objective To investigate the clinical- and cost-effectiveness at 2-year follow-up of providing individual, supervised exercise physiotherapy and/or manual physiotherapy in addition to usual medical care. Method People with hip or knee osteoarthritis meeting the American College of Rheumatology clinical diagnostic criteria were randomised (1:1, concealed, assessor-blinded) to four groups: usual medical care; supervised exercise physiotherapy; manual physiotherapy; or combined exercise and manual physiotherapy. Physiotherapy group participants were provided 10 50-min treatment sessions including booster sessions at 4 and 13 months, in addition to usual care. The primary outcome at 2-year follow-up was incremental cost-utility ratio (ICUR) of each physiotherapy intervention in addition to usual care, compared with usual care alone, from the health system and societal perspectives. To allow interpretation of negative ICURs, we report incremental net benefit (INB). The primary clinical outcome was the Western Ontario and McMaster Osteoarthritis Index (WOMAC). Results Of 206 patients, 186 (90·3%) were retained at 2-year follow-up. Exercise physiotherapy and manual physiotherapy dominated usual care, demonstrating cost savings; combined therapy did not. Exercise therapy had the highest incremental net benefits (INBs), statistically significant at all willingness-to-pay (base-case: societal New Zealand (NZ)$6,312, 95%CI 334 to 12,279; health system NZ$8,065, 95%CI 136 to 15,994). Clinical improvements were superior to usual care only in the exercise physiotherapy group (−28.2 WOMAC points, 95%CI -49.2 to −7.1). No serious adverse events were recorded. Conclusion Individually supervised exercise therapy is cost-effective and clinically effective in addition to usual medical care at 2-year follow-up, and leads to cost savings for the health system and society. Trial registration Prospectively registered with the Australian NZ Clinical Trials Registry, reference ACTRN12608000130369. |
Databáze: | OpenAIRE |
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