Conformationally locked nucleosides. Synthesis of oligodeoxynucleotides containing 3'-amino-3'-deoxy-3'-N,5'(R)-C-ethylenethymidine

Autor:	Vesna Stoisavljevic, Guangyi Wang
Rok vydání:	2000
Předmět:	Molecular Structure Chemistry Stereochemistry Condensation Temperature Nucleosides General Medicine DNA Biochemistry chemistry.chemical_compound Oligodeoxyribonucleotides Genetics Molecular Medicine Nucleic Acid Conformation RNA Thymidine Nuclear Magnetic Resonance Biomolecular
Zdroj:	Nucleosides, nucleotidesnucleic acids. 19(9)
ISSN:	1525-7770
Popis:	3′-Amino-3′-deoxy-5′-O-(4,4′-dimethoxytrityl)-3′-N,5′(R)-C-ethylenethymidine (6) was synthesized starting from 3′-azido-3′-deoxythymidine. Condensation of 6 with 5′-O-(H-phosphonyl)thymidine and 5′-O-(p-nitrophenoxycarbonyl)thymidine derivatives gave dinucleotide and dinucleoside derivatives, respectively, which were incorporated into oligodeoxynucleotides (ODNs). Tm data of the modified ODNs are also presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e91c256b2af38d6973283f83d0428e https://pubmed.ncbi.nlm.nih.gov/11092312 Zobrazit plný text záznamu