IL-22 mediates the oral mucosal wound healing via STAT3 in keratinocytes
| Autor: | Yumei Ding, Lin Liu, Lijuan Zhu, Chenguang Zhang, Lili Chen, Yinying Qu, Ran Yu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Keratinocytes STAT3 Transcription Factor Pathology medicine.medical_specialty Blotting Western Real-Time Polymerase Chain Reaction Collagen Type I Interleukin 22 03 medical and health sciences Mice 0302 clinical medicine Tongue Immunity In vivo Cell Movement medicine Animals STAT3 General Dentistry Cell Proliferation Wound Healing integumentary system biology Cell growth business.industry Interleukins Interleukin Cell Biology General Medicine Fibroblasts Immunohistochemistry Disease Models Animal 030104 developmental biology Otorhinolaryngology Cancer research biology.protein Electrophoresis Polyacrylamide Gel Matrix Metalloproteinase 1 business Wound healing Type I collagen 030215 immunology |
| Zdroj: | Archives of oral biology. 72 |
| ISSN: | 1879-1506 |
| Popis: | Objective Wounds are common in the oral cavity. During wound healing, several cytokines are released, which are probably helpful in providing wound debridement, removal of damaged tissues and microbes. Most of the target cells of IL-22 are epithelial cells, which play an important role in mucosa immunity. Design The function of IL-22 in oral diseases is not well understood. We investigated the expression level of IL-22, collagen I and p-stat3 (Tyr705) via a mice tongue wound model in vivo and detected the effect of IL-22 on the expression of MMP-1, type I collagen and p-stat3 in keratinocytes. Results IL-22 and p-stat3 were associated with wound healing, and STAT3 was activated when the keratinocytes or the tongue tissue were stimulated by IL-22. In addition, IL-22 could mediate gene expression involved in wounds involving keratinocytes, such as type I collagen and MMP-1, which may contribute to scarless healing. Conclusion Our study suggests that IL-22 mediates wound healing via STAT3 in keratinocytes. This study reveals a new role for IL-22 in mediating wound healing. |
| Databáze: | OpenAIRE |
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