Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice
| Autor: | Dana C. Dolinoy, Matthew Savidge, Elizabeth H. Marchlewicz, Luke Montrose, Christopher Faulk, Joseph Kochmanski |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
endocrine system Bisphenol A Time Factors Nutritional Status Biology Toxicology Article Epigenesis Genetic Andrology Mice 03 medical and health sciences chemistry.chemical_compound Phenols Pregnancy Animals Epigenetics Benzhydryl Compounds Gene Genetics Methylation Epigenome DNA Methylation Diet 030104 developmental biology chemistry Prenatal Exposure Delayed Effects DNA methylation Environmental Pollutants Female Genomic imprinting Estrogen receptor alpha |
| Zdroj: | Reproductive Toxicology. 68:154-163 |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2016.07.021 |
| Popis: | Environmental factors, including exogenous exposures and nutritional status, can affect DNA methylation across the epigenome, but effects of exposures on age-dependent epigenetic drift remain unclear. Here, we tested the hypothesis that early-life exposure to bisphenol A (BPA) and/or variable diet results in altered epigenetic drift, as measured longitudinally via target loci methylation in paired mouse tail tissue (3 wks/10 mos old). Methylation was quantified at two repetitive elements (LINE-1, IAP), two imprinted genes (Igf2, H19), and one non-imprinted gene (Esr1) in isogenic mice developmentally exposed to Control, Control+BPA (50 μg/kg diet), Mediterranean, Western, Mediterranean+BPA, or Western+BPA diets. Across age, methylation levels significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect