Adrenal function in adolescence is related to intrauterine and postnatal growth
| Autor: | Kerstin Albertsson-Wikland, Margarita Valūnienė, Rasa Verkauskienė, Indrė Petraitienė |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Medicine (General) puberty Hydrocortisone postnatal growth Intrauterine growth restriction Body Mass Index Cohort Studies chemistry.chemical_compound 0302 clinical medicine Adrenal Glands Medicine Child reproductive and urinary physiology Fetal Growth Retardation General Medicine female genital diseases and pregnancy complications children born appropriate for gestational age (AGA) Child Preschool Infant Small for Gestational Age Female Growth and Development hormones hormone substitutes and hormone antagonists medicine.medical_specialty endocrine system Cortisol awakening response Adolescent DHEAS Infant small for gestational age growth&development Birth weight Body height Puberty 030209 endocrinology & metabolism cortisol Article 03 medical and health sciences Sex Factors R5-920 Dehydroepiandrosterone sulfate Internal medicine Heart rate Humans business.industry Infant Dehydroepiandrosterone medicine.disease 030104 developmental biology Endocrinology Blood pressure chemistry 616.43-053.2 [udc] Linear Models Small for gestational age business Body mass index |
| Zdroj: | Medicina, Kaunas ; Basel : LSMU ; MDPI AG, 2019, vol. 55, no. 5, p. 1-15 Medicina Volume 55 Issue 5 Medicina; Volume 55; Issue 5; Pages: 167 Medicina, Vol 55, Iss 5, p 167 (2019) |
| ISSN: | 1010-660X 1648-9144 |
| Popis: | Background and objectives: Intrauterine growth restriction is thought to be implicated in long-term programming of hypothalamic&ndash pituitary&ndash adrenal axis activity. We investigated adrenal function in adolescents born small for gestational age (SGA) in relation to their postnatal growth and cardiovascular parameters. Materials and Methods: Anthropometric parameters, blood pressure, heart rate, dehydroepiandrosterone sulfate (DHEAS), and cortisol levels were assessed in 102 adolescents aged 11&ndash 14 years followed from birth (47 SGA and 55 born appropriate for gestational age (AGA)). Results: Mean DHEAS levels were higher in SGA adolescents with catch-up growth (SGACU+), compared with AGA. Second-year height velocity and body mass index (BMI) gain during preschool years were positively related to DHEAS levels. Morning cortisol levels and systolic and diastolic blood pressure were higher in SGA adolescents without catch-up growth (SGACU&minus ) compared with AGA. Second-year BMI gain was inversely, and 2&ndash 12 years increase in subscapular skinfold thickness was directly associated with cortisol levels. Size at birth and postnatal growth explained 47.8% and 38.2% of variation in DHEAS and cortisol levels, respectively. Conclusion: Adrenal function in adolescence is affected by prenatal and postnatal growth: small size at birth with postnatal catch-up growth is related to higher DHEAS secretion, whereas increased cortisol levels and blood pressure are higher in short SGA adolescents. |
| Databáze: | OpenAIRE |
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