Stimulated growth hormone concentrations in obese pediatric patients with mild and severe insulin resistance: a pilot study
| Autor: | Beverley Adams-Huet, Perrin C. White, Jon D. Oden, Jill A. Radack |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Radioimmunoassay Context (language use) Stimulation Pilot Projects Growth hormone Growth Hormone-Releasing Hormone Severity of Illness Index Endocrinology Insulin resistance Sex Factors Internal medicine medicine Humans Obesity Insulin-Like Growth Factor I Child Glycoproteins business.industry Human Growth Hormone Patient Selection Area under the curve medicine.disease Growth hormone secretion Insulin-Like Growth Factor Binding Protein 3 Area Under Curve Pediatrics Perinatology and Child Health Positive relationship Female Insulin Resistance business Carrier Proteins |
| Zdroj: | Journal of pediatric endocrinologymetabolism : JPEM. 23(4) |
| ISSN: | 0334-018X |
| Popis: | BACKGROUND GH excess predisposes to insulin resistance (IR). Obese patients have blunted responses to GH stimulation and decreased spontaneous secretion. GH secretion has not been studied in the context of IR.ŗŗ OBJECTIVE To determine whether varying degrees of IR effects GH dynamics in obese children. PATIENTS/DESIGN Patients (all > 10 y) were categorized according to gender and HOMA-IR to have either mild or severe IR. Twenty patients (10 female) with mild IR completed the study, as did 18 (9 female) in the severe group. Each patient underwent a GH stimulation test with GHRH. GH peak and area under the curve (AUC) were compared between the groups. RESULTS Severe IR females had higher peak GH (mean +/- SD, 9.5 +/- 4.4 vs. 5.8 +/- 3.7 ng/dl, p = 0.04) and trended toward higher GH AUC (356 +/- 207 vs. 221 +/- 128, p = 0.06) than mild IR females. There were no differences in GH response in males, CONCLUSIONS There may be a positive relationship between severity of IR and peak GH in obese girls. |
| Databáze: | OpenAIRE |
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