Efficacy and safety of sulforaphane for treatment of mild to moderate depression in patients with history of cardiac interventions: A randomized, double‐blind, placebo‐controlled clinical trial

Autor: Kamyar Moradi, Amir Ashraf-Ganjouei, Fatemeh Ghazizadeh-Hashemi, Nazila Shahmansouri, Shahin Akhondzadeh, Sayna Bagheri, Maryam Mehrpooya, Ahmad Ali Noorbala
Rok vydání: 2021
Předmět:
Zdroj: Psychiatry and Clinical Neurosciences. 75:250-255
ISSN: 1440-1819
1323-1316
DOI: 10.1111/pcn.13276
Popis: AIM Depression has been recognized as one of the disorders associated with cardiac interventions such as percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). In the present study, we evaluated the efficacy and safety of sulforaphane in treatment of depression induced by cardiac interventions. METHODS After initial screening, 66 patients with previous history of at least one cardiac intervention and current mild to moderate depression were randomly assigned to two parallel groups receiving either sulforaphane (n = 33) or placebo (n = 33) for six successive weeks. Efficacy was assessed using the Hamilton Rating Scale for Depression (HAM-D) at baseline and week 2, 4, and 6. Safety of the treatments was checked during the trial period. RESULTS Sixty participants completed the clinical trial (n = 30 in each group). Baseline demographic and clinical parameters were all similar among groups. Repeated measures analysis indicated that the sulforaphane group exhibited greater improvement in HAM-D scores throughout the trial (P
Databáze: OpenAIRE
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