Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection
| Autor: | Rami J. Salib, T.C. Biggs, Jonathan Cooke, Malcolm Richardson, Lilyann Novak-Frazer, Thomas J. Hall, Raymond N. Allan, Matthew Dryden, Zain Al-hindi, Liam M. Grover, Ali A. Salamat, Fenella D. Halstead, Rebecca E. Holding, Sophie C. Cox, B. Oppenheim, Rachel S. Newby |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.drug_class Administration Topical Immunology Antibiotics Drug Evaluation Preclinical Inflammation Biology medicine.disease_cause Microbiology Bioburden 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Animals Humans chemistry.chemical_classification Reactive oxygen species Reactive Oxygen Bacteria Mechanism (biology) Biofilm Fungi Bacterial Infections Antimicrobial 030104 developmental biology chemistry Staphylococcus aureus Biofilms Anti-Infective Agents Local Wound Infection medicine.symptom Reactive Oxygen Species |
| Zdroj: | Dryden, M, Cooke, J, Salib, R J, Holding, R, Biggs, T, Salamat, A A, Allan, R N, Newby, R, Halstead, F, Oppenheim, B, Hall, T, Cox, S C, Grover, L M, Alhindi, Z, Novak-Frazer, L & Richardson, M 2017, ' Reactive Oxygen: a novel antimicrobial mechanism for targeting biofilm-associated infection ', Journal of Global Antimicrobial Resistance . https://doi.org/10.1016/j.jgar.2016.12.006 |
| ISSN: | 2213-7173 |
| Popis: | The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with biofilm and chronic inflammation. Bacterial biofilms are a significant problem in clinical settings owing to their increased tolerance towards conventionally prescribed antibiotics and their propensity for selection of further antibacterial resistance. There is therefore a pressing need for the development of alternative therapeutic strategies that can improve antibiotic efficacy towards biofilms. ROS has been successful in treating chronic wounds and in clearing multidrug-resistant organisms, including methicillin-resistant Staphylococcus aureus (MRSA), and carbapenemase-producing isolates from wounds and vascular line sites. There is significant antifungal activity of ROS against planktonic and biofilm forms. Nebulised ROS has been evaluated in limited subjects to assess reductions in bioburden in chronically colonised respiratory tracts. The antibiofilm activity of ROS could have great implications for the treatment of a variety of persistent respiratory conditions. Use of ROS on internal prosthetic devices shows promise. Avariety of novel delivery mechanisms are being developed to apply ROS activity to different anatomical sites. |
| Databáze: | OpenAIRE |
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