Placental Transfer of Radioactive Digitoxin in Pregnant Women and its Fetal Distribution
| Autor: | Ernest J. Plotz, George T. Okita, Frederick D. Smith, John H. Curry, M. Edwards Davis |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
medicine.medical_specialty
Fetus Kidney Digitalis Physiology Digitoxin Placenta Gallbladder Fetal heart Biology medicine.anatomical_structure Endocrinology Pregnancy Internal medicine medicine Humans Gestation Distribution (pharmacology) Female Cardiology and Cardiovascular Medicine Cardiac glycoside medicine.drug |
| Zdroj: | Circulation Research. 4:376-380 |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/01.res.4.4.376 |
| Popis: | Placental transfer of radioactive C 14 -digitoxin was investigated in four pregnant women. The concentration of the labeled drug and its metabolic products in the various fetal organs was determined. Less than 1 per cent of the administered glycoside was detected in the fetus as unchanged digitoxin and less than 3.5 per cent as its metabolites. The fetal heart and kidney of 11 to 12 weeks gestation had the highest concentrations. However, at near term the fetal liver, gallbladder and intestine had somewhat similar concentrations. Metabolic conversion of the cardiac glycoside by fetal liver as well as biliary excretion is indicated from the tissue distribution data. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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