Vancomycin-aminoglycoside combinations in therapy of endocarditis caused byEnterococcus species andStreptococcus bovis
| Autor: | Catherine Leport, J. L. Vildé, A. Buré, J.M. Besnier |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Microbiology (medical) medicine.medical_specialty Time Factors medicine.medical_treatment Kidney Gastroenterology chemistry.chemical_compound Medical microbiology Species Specificity Valve replacement Vancomycin Streptococcal Infections Internal medicine medicine Humans Endocarditis Aged Creatinine business.industry Aminoglycoside Drug Synergism Endocarditis Bacterial General Medicine Middle Aged medicine.disease Anti-Bacterial Agents Surgery Regimen Aminoglycosides Infectious Diseases chemistry Drug Therapy Combination Creatinine.serum business medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 9:130-133 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/bf01963638 |
| Popis: | Between 1974 and 1986, five patients with enterococcal endocarditis (three of whom had a prosthetic valve) and three patients with Streptococcus bovis endocarditis were treated with a combination of vancomycin and an aminoglycoside for a mean duration of 40 days. This regimen was prescribed because of allergy to beta-lactam (n = 7) and/or failure of previous treatment (n = 4). Three of the eight patients underwent valve replacement. In the six evaluable patients cure was achieved with the vancomycin-aminoglycoside combination. An increase of the creatinine serum levels was observed in all cases but it was never necessary to discontinue treatment, adjustment of the vancomycin and aminoglycoside dosage according to the serum and/or serum creatinine levels allowing continuation of therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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