Low thoracic muscle radiation attenuation is associated with postoperative pneumonia following partial hepatectomy for colorectal metastasis
| Autor: | David P J van Dijk, Sander S. Rensen, Frank H. van Tiel, Ulf P. Neumann, Gregory van der Kroft, Kristoffer Ostridge, Steven W.M. Olde Damink, Malcolm A. West, Bianca T. A. de Greef, Cornelis H. C. Dejong |
|---|---|
| Přispěvatelé: | Surgery, RS: NUTRIM - R2 - Liver and digestive health, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI Management (9), RS: MHeNs - R3 - Neuroscience, MUMC+: KIO Kemta (9), Klinische Neurowetenschappen, Epidemiologie, MUMC+: MA Heelkunde (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
PREDICTOR BODY-COMPOSITION SURGERY VISCERAL ADIPOSITY Logistic regression Gastroenterology 03 medical and health sciences Postoperative Complications 0302 clinical medicine Internal medicine medicine Hepatectomy Humans Infection control COMPUTED-TOMOGRAPHY SARCOPENIC OBESITY Prospective Studies Respiratory system Risk factor PULMONARY COMPLICATIONS Muscle Skeletal Hepatology business.industry MORTALITY Confounding Cancer Skeletal muscle Pneumonia medicine.disease CANCER medicine.anatomical_structure 030220 oncology & carcinogenesis SKELETAL-MUSCLE 030211 gastroenterology & hepatology HEALTH Colorectal Neoplasms business Radiation attenuation |
| Zdroj: | HPB, 22(7), 1011-1019. ELSEVIER SCI LTD |
| ISSN: | 1365-182X |
| Popis: | BACKGROUND: Low skeletal muscle radiation attenuation (SM-RA) is indicative of myosteatosis and diminished muscle function. It is predictive of poor outcome following oncological surgery in several cancer types. Postoperative pneumonia is a known risk factor for increased postoperative mortality. We hypothesized that low SM-RA of the respiratory muscles at the 4th thoracic-vertebra (T4) is associated with postoperative pneumonia following liver surgery.METHODS: Postoperative pneumonia was identified using prospective infection control data. Computed tomography body composition analysis was performed at the L3-and T4 level to determine SM-RA. Body composition variables were corrected for confounders and related to postoperative pneumonia and admission time by multivariable logistic regression.RESULTS: Body composition analysis of 180 patients was performed. Twenty-one patients developed postoperative pneumonia (11.6%). Multivariable analysis showed that low T4 SM-RA as well as low L3 SM-RA were significantly associated with postoperative pneumonia (OR 3.65, 95% CI 1.41-9.49, p < 0.01) and (OR 3.22, 95% CI 1.20-8.61, p = 0.02, respectively).CONCLUSION: Low SM-RA at either the L3-or T4-level is associated with a higher risk of postoperative pneumonia following CLRM resection. |
| Databáze: | OpenAIRE |
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