The Bristol prostate cancer pilot screening study--a 3-year follow-up
| Autor: | J C Gingell, Simon Brewster, J.P. Astley, T. Kemple, A.G. MacIver |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Urology Pilot Projects Disease Health centre Prostate cancer Prostate Internal medicine Biopsy medicine Humans Mass Screening Screening study Aged Gynecology medicine.diagnostic_test business.industry Cancer Prostatic Neoplasms Middle Aged Prostate-Specific Antigen medicine.disease Elevated PSA medicine.anatomical_structure Patient Satisfaction business Family Practice Follow-Up Studies |
| Zdroj: | British journal of urology. 74(5) |
| ISSN: | 0007-1331 |
| Popis: | Objective To undertake a follow-up study of 472 men who were screened 3 years previously, in genral practice, forprostate cancer, and to investigate the efficacy and patient acceptability of a 3-year screening interval. Subjects and methods Eligible men (n=472) were sent postal invitations to attend their Health Centre in North Bristol. Serum prostate-specific antigen (PSA) was the initial screening test. Men with PSA >4 ng/ml (Hybritech) were referred to the Department of Urology for digital rectal examintation and trasectal ultrasound ± biopsy. Results A total of 132 (28%) men were excluded because of intercurrent illness, death and migration. Two hundred of 340 (59%) men were re-screened. Thirty seven men had an elevated PSA and were referred as above. Seventeen men had prostatic biopsies, resulting in the diagnosis of six carcinamas; five were localized to the prostate and one was metastatic. In the latter patient, the PSA had risen from 2 to 120 ng/ml over 3 years. Conclusion Serum PSA alone can be used as an acceptable repeat screening test to detect prostate cancer in genral practice, but 3-year repeat screening will not always protect the individual against the interval development of metastatic disease. |
| Databáze: | OpenAIRE |
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