Mitochondrial quality control in the cardiac system: An integrative view
| Autor: | Yan Burelle, Virgilio J. J. Cadete, Goutham Vasam, Keir J. Menzies |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Sustained contraction Myocardium media_common.quotation_subject Metabolic reprogramming Cell type specific Biology Mitochondria Heart Oxidative Stress 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Mitophagy Proteostasis Animals Humans Molecular Medicine Quality (business) Control (linguistics) Molecular Biology Neuroscience 030217 neurology & neurosurgery Peptide Hydrolases media_common |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:782-796 |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/j.bbadis.2018.11.018 |
| Popis: | Recent studies have led to the discovery of multiple mitochondrial quality control (mQC) processes that operate at various scales, ranging from the degradation of proteins by mitochondrial proteases to the degradation of selected cargos or entire organelles in lysosomes. While the mechanisms governing these mQC processes are progressively being delineated, their role and importance remain unclear. Converging evidence however point to a complex system whereby multiple and partly overlapping processes are recruited to orchestrate a cell type specific mQC response that is adapted to the physiological state and level of stress encountered. Knowledge gained from basic model systems of mQC therefore need to be integrated within organ-specific (patho)physiological frameworks. Building on this notion, this article focuses on mQC in the heart, where developmental metabolic reprogramming, sustained contraction, and multiple pathophysiological conditions pose broadly different constraints. We provide an overview of current knowledge of mQC processes, and discuss their implication in cardiac mQC under normal and diseased conditions. |
| Databáze: | OpenAIRE |
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