Increased placental macrophages and a pro‐inflammatory profile in placentas and maternal serum in infants with a decreased growth rate in the third trimester of pregnancy
| Autor: | Bernadette Baker, Alexander E. P. Heazell, Rebecca Jones, Helen Bischof, Tatiana Guevara, Susan L. Greenwood, Megan C. Sharps |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent placenta Placenta Pregnancy Trimester Third Immunology Inflammation macrophage Andrology fetal growth restriction 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Pregnancy Immunology and Allergy Medicine Humans 030219 obstetrics & reproductive medicine Fetal Growth Retardation business.industry Macrophages Infant Newborn Obstetrics and Gynecology medicine.disease Pathophysiology 030104 developmental biology medicine.anatomical_structure Reproductive Medicine chemistry inflammation Infant Small for Gestational Age Immunohistochemistry Uric acid Small for gestational age Cytokines Female medicine.symptom business CD163 serum |
| Zdroj: | Sharps, M C, Baker, B C, Guevara, T, Bischof, H, Jones, R L, Greenwood, S L & Heazell, A E P 2020, ' Increased placental macrophages and a pro-inflammatory profile in placentas and maternal serum in infants with a decreased growth rate in the third trimester of pregnancy ', American Journal of Reproductive Immunology, vol. 84, no. 3, e13267 . https://doi.org/10.1111/aji.13267 |
| DOI: | 10.1111/aji.13267 |
| Popis: | Problem: There is growing evidence for the role of placental inflammation in the pathophysiology of pregnancy complications including fetal growth restriction (FGR). This study aimed to characterize the inflammatory profile in the maternal circulation and the placenta of infants who were growth restricted and those that were small for gestational age (SGA). Method of study: Placental villous tissue and maternal serum were obtained from pregnancies where infants were SGA at birth or who had a decreasing growth rate (≥25 centiles) across the third trimester. Immunohistochemical and histological analyses of placental samples were conducted for macrophage number, alongside vascular and cell turnover analysis. Inflammatory profile was analyzed in maternal and placental compartments via ELISAs and multiplex assays. Results: There were significantly more CD163 + macrophages in placentas of infants with a decreased growth rate compared to controls, but not in SGA infants (median 8.6/ nuclei vs 3.8 and 2.9, P =.008 and P =.003, respectively). Uric acid (P =.0007) and IL-8 (P =.0008) were increased in placentas, and S100A8 (P |
| Databáze: | OpenAIRE |
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