Identification of risk factors for central nervous system metastasis in patients with breast cancer with neurologic symptoms
| Autor: | Antelmo Abelardo Meneses-García, Bernardo Cacho-Díaz, Alberto Alvarado-Miranda, Laura G. Mendoza-Olivas, Cynthia Villarreal-Garza, Karen Salmerón-Moreno, Mariana Chavez-MacGregor, Alejandra Alvarez-Alvarez, Nancy Reynoso-Noverón |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Multivariate analysis Breast Neoplasms Metastasis Central Nervous System Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Risk Factors Interquartile range Internal medicine medicine Humans 030212 general & internal medicine Neoplasm Metastasis Mexico business.industry Brain Cancer Odds ratio Middle Aged Prognosis medicine.disease Confidence interval Oncology 030220 oncology & carcinogenesis Female business Brain metastasis |
| Zdroj: | Cancer. 126:3456-3463 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.32928 |
| Popis: | BACKGROUND The current study was performed to identify factors that are present at the time of breast cancer (BC) diagnosis that are associated with a higher rate of central nervous system metastasis (CNSm). METHODS The authors analyzed a database of patients with a confirmed diagnosis of BC who were referred for a neuro-oncology consultation at the National Cancer Institute in Mexico City, Mexico, from June 2009 to June 2017. Information was collected prospectively and included demographic, pathologic, and clinical data at the time of diagnosis of BC. Bivariate and multivariate logistic regression models were built to estimate the associations between the development of CNSm and the time after BC diagnosis. RESULTS Among 970 patients with BC, 263 (27%) were diagnosed with CNSm. The median time from BC diagnosis to the development of CNSm was 33 months (interquartile range, 15-76 months). After multivariate analysis, age |
| Databáze: | OpenAIRE |
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