Association of high post-transplant soluble CD30 serum levels with chronic allograft nephropathy
| Autor: | Patricia C. Grenzi, Marcello Franco, Maria Gerbase-DeLima, Erika F. Campos, Claudia Rosso Felipe, Helio Tedesco-Silva, Jose O. Medina-Pestana, Maria Fernanda Soares |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent Immunology Ki-1 Antigen Renal function Single Center Gastroenterology chemistry.chemical_compound Isoantibodies Chronic allograft nephropathy Internal medicine medicine Humans Immunology and Allergy Child Kidney transplantation Aged Retrospective Studies Transplantation Creatinine Kidney business.industry Hazard ratio Histocompatibility Antigens Class II Area under the curve Middle Aged medicine.disease Kidney Transplantation surgical procedures operative medicine.anatomical_structure chemistry Child Preschool Female Kidney Diseases business Follow-Up Studies |
| Zdroj: | Transplant Immunology. 29:34-38 |
| ISSN: | 0966-3274 |
| DOI: | 10.1016/j.trim.2013.07.003 |
| Popis: | The purpose of this study was to evaluate the association of post-transplant soluble CD30 (sCD30) levels, isolated or in combination with of anti-HLA class II antibodies and of serum creatinine levels, with kidney graft loss due to chronic allograft nephropathy (CAN), and type of lesions in graft biopsies for cause. The study comprised 511 first kidney graft recipients, transplanted at a single center, with a graft functioning for at least 2.8 years. A single blood sample was collected from each patient. sCD30 levels were determined by ELISA, and HLA antibodies by Luminex assay. The minimum follow-up after testing was 9.3 years. High sCD30 levels, set at sCD30 ≥ 34.15 ng/mL, the presence of HLA class II antibodies, and serum creatinine ≥ 1.9 mg/dL were independently associated with CAN-graft loss (P values |
| Databáze: | OpenAIRE |
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