Vitamin D in youth with Type 1 diabetes: prevalence of insufficiency and association with insulin resistance in the SEARCH Nutrition Ancillary Study
| Autor: | N. S. The, J. L. Crandell, J. M. Lawrence, I. B. King, D. Dabelea, S. M. Marcovina, R. B. D'Agostino, J. M. Norris, C. Pihoker, E. J. Mayer-Davis |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Logistic regression vitamin D deficiency Article Young Adult Endocrinology Insulin resistance Diabetes mellitus Internal medicine Internal Medicine medicine Vitamin D and neurology Humans Vitamin D Prospective cohort study Child Type 1 diabetes business.industry Confounding medicine.disease Vitamin D Deficiency Diabetes Mellitus Type 1 Female Insulin Resistance business Epidemiologic Methods |
| DOI: | 10.17615/seyh-ve11 |
| Popis: | Aims To determine the prevalence of plasma vitamin D (25-dihydroxyvitamin D) insufficiency in individuals with Type 1 diabetes and to determine the cross-sectional and longitudinal associations of plasma vitamin D with insulin resistance. Methods Participants from the SEARCH for Diabetes in Youth Study [n = 1426; mean age 11.2 years (sd 3.9)] had physician-diagnosed Type 1 diabetes [diabetes duration mean 10.2 months (sd 6.5)] with data available at baseline and follow-up (approximately 12 and 24 months after baseline). Insulin resistance was estimated using a validated equation. Cross-sectional and longitudinal multivariate logistic regression models were used to determine the association of plasma vitamin D with insulin resistance, adjusting for potential confounders. Results Forty-nine per cent of individuals had plasma vitamin D |
| Databáze: | OpenAIRE |
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