Derivatives of the cationic plant alkaloids berberine and palmatine amplify protonophorous activity of fatty acids in model membranes and mitochondria

Autor:	Inna I. Severina, A. G. Rogov, Tatiana A. Trendeleva, Antonina V. Pustovidko, Tatiana I. Rokitskaya, Vladimir P. Skulachev, Yuri N. Antonenko, Renata A. Zvyagilskaya, Ruben A. Simonyan, Boris V. Chernyak, Konstantin G. Lyamzaev
Rok vydání:	2013
Předmět:	Liposome Membranes Berberine Plastoquinone Berberine Alkaloids Fatty Acids Palmatine Cell Biology Mitochondrion Mitochondria 2 4-Dinitrophenol chemistry.chemical_compound Alkaloids Membrane chemistry Biochemistry Cations Proton transport Molecular Medicine Molecular Biology Hydrogen
Zdroj:	Mitochondrion. 13:520-525
ISSN:	1567-7249
DOI:	10.1016/j.mito.2012.09.006
Popis:	Previously it has been shown by our group that berberine and palmatine, penetrating cations of plant origin, when conjugated with plastoquinone (SkQBerb and SkQPalm), can accumulate in isolated mitochondria or in mitochondria of living cells and effectively protect them from oxidative damage. In the present work, we demonstrate that SkQBerb, SkQPalm, and their analogs lacking the plastoquinone moiety (C10Berb and C10Palm) operate as mitochondria-targeted compounds facilitating protonophorous effect of free fatty acids. These compounds induce proton transport mediated by small concentrations of added fatty acids both in planar and liposomal model lipid membranes. In mitochondria, such an effect can be carried out by endogenous fatty acids and the adenine nucleotide translocase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d8346faa7edc80851bd228e62c560c https://doi.org/10.1016/j.mito.2012.09.006 Zobrazit plný text záznamu Full Text from ScienceDirect