Synthesis, characterization and antitumor activities of some novel thiazinones and thiosemicarbazones derivatives

Autor:	Kiran George, Selvam Athavan Alias Anand, Senthamaraikannan Kabilan, Nisha Susan Thomas
Rok vydání:	2020
Předmět:	Inorganic Chemistry chemistry.chemical_compound 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Semicarbazone Combinatorial chemistry 0104 chemical sciences
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 195:821-829
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426507.2020.1757672
Popis:	Two series of thiazinone and thiosemicarbazone derivatives (1-12) were synthesized using 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (ABNs) and 3–alkyl–2,6–diarylpiperidin–4–ones as the starting materials. The structures of newly synthesized compounds were established on the basis of FT–IR, NMR spectroscopy and mass spectrometry. From the spectroscopic data, we identified that the cyclization reaction of thioamide with dialkyl acetylenedicarboxylate selectively gives six membered methyl 2-(2-(2,4-disubstituted-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinyl)-4-oxo-4H-1,3-thiazine-6-carboxylates (1-6). In order to investigate the antitumor activities of the synthesized compounds, in vitro cytotoxicity studies were carried out using human prostate cancer cell lines. Tested compounds showed good/moderate activities against cancer cell lines and further investigation carried out by live/dead assay.
Databáze:	OpenAIRE
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