MDA5+ Dermatomyositis Is Associated with Stronger Skin Type I Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript
| Autor: | Marie Jachiet, Florence Cordoliani, Antonio José Alberdi, D. Boccara, R. Amode, Hélène Le Buanec, Marc Delord, Jacqueline Lehmann-Che, Clémence Lepelletier, Jennifer Wong, Alexandre How-Kit, Laure Frumholtz, Charles Cassius, Adèle de Masson, Sylvie Dubanchet, Maxime Battistella, Jean-David Bouaziz, Justine Poirot, Martine Bagot, Marine Merandet, Armand Bensussan |
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| Přispěvatelé: | Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), CHU UCL Namur, Université Catholique de Louvain = Catholic University of Louvain (UCL), Groupe d'Etude des Maladies Systémiques En Dermatologie (EMSED - Paris), Société Française de Dermatologie et de Pathologie Sexuellement Transmissible (SFDPST - Paris), Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Direction à la recherche clinique et à l'innovation [CH de Versailles André Mignot] (DRCI), Centre Hospitalier de Versailles André Mignot (CHV), Laboratoire de pathologie [AP-HP Hôpital Saint-Louis], Fondation Jean Dausset CEPH, Service de chirurgie plastique et reconstructive [Hôpital Saint Louis], Service d'Hémato-oncologie [CHU Saint-Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université de Paris (UP), Le Buanec, Hélène, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Cité (UPCité), UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Dermatologie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Interferon-Induced Helicase IFIH1 Skin type Dermatology [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biochemistry Dermatomyositis Transcriptome Young Adult 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Interferon medicine Humans Molecular Biology [SDV.BC] Life Sciences [q-bio]/Cellular Biology ComputingMilieux_MISCELLANEOUS Aged Autoantibodies Oligonucleotide Array Sequence Analysis Skin 030304 developmental biology Aged 80 and over 030203 arthritis & rheumatology 0303 health sciences business.industry Gene Expression Profiling MDA5 Cell Biology Middle Aged medicine.disease Fold change Up-Regulation 3. Good health Gene Expression Regulation Case-Control Studies Interferon Type I Cancer research Female business medicine.drug |
| Zdroj: | Journal of Investigative Dermatology Journal of Investigative Dermatology, Nature Publishing Group, 2020, 140 (6), pp.1276-1279.e7. ⟨10.1016/j.jid.2019.10.020⟩ The Journal of investigative dermatology, Vol. 140, no. 6, p. 1276-1279.e7 (2020) |
| ISSN: | 0022-202X 1523-1747 |
| DOI: | 10.1016/j.jid.2019.10.020⟩ |
| Popis: | TO THE EDITOR, Dermatomyositis (DM) is a chronic inflammatory and autoimmune disorder belonging to the idiopathic inflammatory myopathies affecting primarily skin and muscle with variable extent. Disease mechanism comprehension is growing, with a pivotal role of both the innate and adaptive immune system and involvement of both cellular and humoral actors (Nagaraju and Lundberg, 2011). [...] |
| Databáze: | OpenAIRE |
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