Acute effects of acylated ghrelin on salbutamol-induced metabolic actions in humans
| Autor: | D. H. St-Pierre, Fabio Broglio, A. Dotta, Elisa Calvi, M. Tomelini, Sara Belcastro, Ezio Ghigo, Ilaria Olivetti, Andrea Benso, Elena Gramaglia |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Acute effects
Free fatty acids Ghrelin Glucose Insulin Salbutamol β-adrenergic system Adrenergic beta-2 Receptor Agonists Adult Albuterol Blood Glucose Fatty Acids Nonesterified Humans Male Endocrinology Endocrinology Diabetes and Metabolism Medicine (all) medicine.medical_specialty medicine.medical_treatment Acylated ghrelin Bolus (medicine) Diabetes mellitus Internal medicine Medicine Saline business.industry Fatty Acids medicine.disease Diabetes and Metabolism Nonesterified business medicine.drug |
| Zdroj: | Endocrine. 48(3) |
| ISSN: | 1559-0100 |
| Popis: | The aim of this study is to describe a potential modulatory effect of acute acylated ghrelin (AG) administration on the glucose, insulin, and free fatty acids (FFA) responses to salbutamol (SALBU). Six healthy young male volunteers underwent the following four testing sessions in random order at least 7 days apart: (a) acute AG administration (1.0 μg/kg i.v. as bolus at 0′); (b) SALBU infusion (0.06 μg/kg/min i.v. from −15′ to +45′); (c) SALBU infusion + AG; and (d) isotonic saline infusion. Blood samples for glucose, insulin, and FFA levels were collected every 15 min. As expected, with respect to saline, SALBU infusion induced a remarkable increase in glucose (10.8 ± 5.6 mmol/l × min; P < 0.05), insulin (2436.8 ± 556.9 pmol/l × min; P < 0.05), and FFA (18.9 ± 4.5 mmol/l × min; P < 0.01) levels. A significant increase in glucose (7.4 ± 3.9 mmol/l × min; P < 0.05) and FFA levels (10.0 ± 2.8 mmol/l × min; P < 0.01) without significant variations in insulin levels were recorded after AG administration. Interestingly, the hyperglycemic effect of AG appeared to be significantly potentiated during SALBU infusion (26.7 ± 4.8 mmol/l × min; P < 0.05). On the other hand, the stimulatory effect of SALBU on insulin and FFA was not significantly modified by AG administration. The results of this study show that acute AG administration has a synergic effect with β2-adrenergic receptor activation by SALBU on blood glucose increase, suggesting that their pharmacological hyperglycemic action takes place via different mechanisms. On the other hand, AG has a negligible influence on the other pharmacological metabolic effects of SALBU infusion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink