Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes

Autor: Thomas Lavstsen, Anja T. R. Jensen, Lasse S Vestergaard, Lars Hviid, Pamela Magistrado, Trine Staalsoe, John Lusingu, Jesper Christensen, Rob Hermsen, Colin J. Sutherland, Ali Salanti, Morten Nielsen, Thor G. Theander, Antonella Chiucchiuini, Sarah Sharp, Robert W. Sauerwein, Louise Joergensen
Rok vydání: 2004
Předmět:
Zdroj: Journal of Experimental Medicine, 199, 1179-90
Jensen, A T R, Magistrado, P, Sharp, S, Joergensen, L, Lavstsen, T, Chiucchiuini, A, Salanti, A, Vestergaard, L S, Lusingu, J P, Hermsen, R, Sauerwein, R, Christensen, J, Nielsen, M A, Hviid, L, Sutherland, C, Staalsoe, T & Theander, T G 2004, ' Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes ', Journal of Experimental Medicine, vol. 199, no. 9, pp. 1179-90 . https://doi.org/10.1084/jem.20040274
The Journal of Experimental Medicine
Journal of Experimental Medicine, 199, 9, pp. 1179-90
ISSN: 0022-1007
DOI: 10.1084/jem.20040274
Popis: Item does not contain fulltext Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P. falciparum malaria. Parasites causing severe malaria in nonimmune patients tend to express a restricted subset of VSA (VSA(SM)) that differs from VSA associated with uncomplicated malaria and asymptomatic infection (VSA(UM)). We compared var gene transcription in unselected P. falciparum clone 3D7 expressing VSA(UM) to in vitro-selected sublines expressing VSA(SM) to identify PfEMP1 responsible for the VSA(SM) phenotype. Expression of VSA(SM) was accompanied by up-regulation of Group A var genes. The most prominently up-regulated Group A gene (PFD1235w/MAL7P1.1) was translated into a protein expressed on the infected RBC surface. The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria.
Databáze: OpenAIRE