The senescence-associated secretory phenotype: Fueling a wound that never heals
| Autor: | Tanya Pulido, Michael C. Velarde, Fatouma Alimirah |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Immunosenescence medicine.medical_treatment Inflammation Bioinformatics Wound care Diabetes mellitus Neoplasms Paracrine Communication medicine Humans Cellular Senescence Senescence-Associated Secretory Phenotype Chemotherapy Wound Healing integumentary system business.industry Cancer medicine.disease Pathophysiology Wounds and Injuries medicine.symptom Wound healing business Developmental Biology |
| Zdroj: | Mechanisms of ageing and development. 199 |
| ISSN: | 1872-6216 |
| Popis: | Wound healing is impaired with advanced age and certain chronic conditions, such as diabetes and obesity. Moreover, common cancer treatments, including chemotherapy and radiation, can cause unintended tissue damage and impair wound healing. Available wound care treatments are not always effective, as some wounds fail to heal or recur after treatment. Hence, a more thorough understanding of the pathophysiology of chronic, nonhealing wounds may offer new ideas for the development of effective wound care treatments. Cancers are sometimes referred to as wounds that never heal, sharing mechanisms similar to wound healing. We describe in this review how cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to chronic wounds versus cancer. |
| Databáze: | OpenAIRE |
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