Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort

Autor: Clayton J. Vesperman, Dane B. Cook, Barbara B. Bendlin, Vincent Pozorski, Sterling C. Johnson, Yue Ma, Bruce P. Hermann, Elizabeth A. Boots, Ozioma C. Okonkwo, Lena L. Law, Mark A. Sager, Catherine L. Gallagher, Sanjay Asthana, Cynthia M. Carlsson, Jennifer M. Oh, Ryan J. Dougherty, Howard A. Rowley
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Aging
medicine.medical_specialty
Cognitive Neuroscience
behavioral disciplines and activities
050105 experimental psychology
lcsh:RC346-429
lcsh:RC321-571
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Alzheimer Disease
Risk Factors
Internal medicine
mental disorders
White matter hyperintensities
Humans
Medicine
Aerobic exercise
0501 psychology and cognitive sciences
Risk factor
Family history
Cardiorespiratory fitness
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
lcsh:Neurology. Diseases of the nervous system
Aged
business.industry
05 social sciences
Brain
Middle Aged
Magnetic Resonance Imaging
White Matter
Hyperintensity
Blood pressure
Neurology
Cohort
Cardiology
Female
Neurology (clinical)
business
Body mass index
Alzheimer’s disease
030217 neurology & neurosurgery
Zdroj: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-7 (2018)
ISSN: 1758-9193
Popis: Background Age is the cardinal risk factor for Alzheimer’s disease (AD), and white matter hyperintensities (WMH), which are more prevalent with increasing age, may contribute to AD. Higher cardiorespiratory fitness (CRF) has been shown to be associated with cognitive health and decreased burden of AD-related brain alterations in older adults. Accordingly, the aim of this study was to determine whether CRF attenuates age-related accumulation of WMH in middle-aged adults at risk for AD. Methods One hundred and seven cognitively unimpaired, late-middle-aged adults from the Wisconsin Registry for Alzheimer’s Prevention underwent 3 T magnetic resonance imaging and performed graded maximal treadmill exercise testing from which we calculated the oxygen uptake efficiency slope (OUES) as our measure of CRF. Total WMH were quantified using the Lesion Segmentation Tool and scaled to intracranial volume. Linear regression adjusted for APOE4 carriage, family history, body mass index, systolic blood pressure, and sex was used to examine relationships between age, WMH, and CRF. Results As expected, there was a significant association between age and WMH (p
Databáze: OpenAIRE
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