| Autor: |
Bridget P. Keenan, Elizabeth E. McCarthy, Arielle Ilano, Hai Yang, Li Zhang, Kathryn Allaire, Zenghua Fan, Tony Li, David S. Lee, Yang Sun, Alexander Cheung, Diamond Luong, Hewitt Chang, Brandon Chen, Jaqueline Marquez, Brenna Sheldon, Robin K. Kelley, Chun Jimmie Ye, Lawrence Fong |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Cell Reports. 40:111384 |
| ISSN: |
2211-1247 |
| Popis: |
Suppressive myeloid cells can contribute to immunotherapy resistance, but their role in response to checkpoint inhibition (CPI) in anti-PD-1 refractory cancers, such as biliary tract cancer (BTC), remains elusive. We use multiplexed single-cell transcriptomic and epitope sequencing to profile greater than 200,000 peripheral blood mononuclear cells from advanced BTC patients (n = 9) and matched healthy donors (n = 8). Following anti-PD-1 treatment, CD14 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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